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Primary prevention of variceal hemorrhage.
- Source :
-
Current gastroenterology reports [Curr Gastroenterol Rep] 2011 Feb; Vol. 13 (1), pp. 3-9. - Publication Year :
- 2011
-
Abstract
- Variceal hemorrhage is one of the leading causes of death in patients with cirrhosis, with the 6-week mortality after each episode ranging from 15% to 20%. The two main strategies for primary prevention of variceal bleeding in patients with cirrhosis and varices are the administration of nonselective β-blockers or the obliteration of varices with use of endoscopic band ligation. In this review, we present and critically review the latest data on primary prevention of variceal hemorrhage. We advocate that nonselective β-blockers should be the first line therapy, and band ligation should be offered only in cases of intolerance or side effects. We also explore potential future therapies based on preliminary experimental and clinical data.
- Subjects :
- Adrenergic beta-Antagonists therapeutic use
Combined Modality Therapy
Endoscopy, Gastrointestinal methods
Esophageal and Gastric Varices etiology
Gastrointestinal Hemorrhage etiology
Humans
Ligation methods
Liver Cirrhosis physiopathology
Primary Prevention methods
Primary Prevention trends
Esophageal and Gastric Varices prevention & control
Gastrointestinal Hemorrhage prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1534-312X
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current gastroenterology reports
- Publication Type :
- Academic Journal
- Accession number :
- 21086193
- Full Text :
- https://doi.org/10.1007/s11894-010-0160-x