Back to Search
Start Over
Eph/ephrin molecules--a hub for signaling and endocytosis.
- Source :
-
Genes & development [Genes Dev] 2010 Nov 15; Vol. 24 (22), pp. 2480-92. - Publication Year :
- 2010
-
Abstract
- The development, homeostasis, and regeneration of complex organ systems require extensive cell-cell communication to ensure that different cells proliferate, migrate, differentiate, assemble, and function in a coordinated and timely fashion. Eph receptor tyrosine kinases and their ephrin ligands are critical regulators of cell contact-dependent signaling and patterning. Eph/ephrin binding can lead to very diverse biological readouts such as adhesion versus repulsion, or increased versus decreased motility. Accordingly, depending on cell type and context, a limited and conserved set of receptor-ligand interactions is translated into a large variety of downstream signaling processes. Recent evidence indicates that the endocytosis of Eph/ephrin molecules, together with the internalization of various associated tissue-specific effectors, might be one of the key principles responsible for such highly diverse and adaptable biological roles. Here, we summarize recent insights into Eph/ephrin signaling and endocytosis in three biological systems; i.e., the brain, intestine, and vasculature.
Details
- Language :
- English
- ISSN :
- 1549-5477
- Volume :
- 24
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Genes & development
- Publication Type :
- Academic Journal
- Accession number :
- 21078817
- Full Text :
- https://doi.org/10.1101/gad.1973910