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Analysis of optineurin in frontotemporal lobar degeneration.

Authors :
Rollinson S
Bennion J
Toulson G
Halliwell N
Usher S
Snowden J
Richardson A
Neary D
Mann D
Pickering-Brown SM
Source :
Neurobiology of aging [Neurobiol Aging] 2012 Feb; Vol. 33 (2), pp. 425.e1-2. Date of Electronic Publication: 2010 Nov 12.
Publication Year :
2012

Abstract

Frontotemporal lobar degeneration (FTLD) can occur jointly with amyotrophic lateral sclerosis (ALS), and these 2 conditions share a genetic risk factor on chromosome 9. It has been reported that mutations in optineurin (OPTN) can cause ALS. Therefore, we sequenced OPTN in 371 FTLD cases but no mutations were detected, suggesting changes in OPTN do not cause FTLD.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)

Subjects

Subjects :
Aged
Aged, 80 and over
Cell Cycle Proteins
Female
Humans
Male
Membrane Transport Proteins
Prevalence
Risk Assessment
Risk Factors
Tissue Distribution
United Kingdom epidemiology
Frontotemporal Lobar Degeneration epidemiology
Frontotemporal Lobar Degeneration genetics
Genetic Predisposition to Disease epidemiology
Genetic Predisposition to Disease genetics
Polymorphism, Single Nucleotide genetics
Transcription Factor TFIIIA genetics

Details

Language :
English
ISSN :
1558-1497
Volume :
33
Issue :
2
Database :
MEDLINE
Journal :
Neurobiology of aging
Publication Type :
Academic Journal
Accession number :
21074902
Full Text :
https://doi.org/10.1016/j.neurobiolaging.2010.10.002
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