Back to Search
Start Over
Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene.
- Source :
-
Experimental dermatology [Exp Dermatol] 2010 Nov; Vol. 19 (11), pp. 1026-8. Date of Electronic Publication: 2010 Sep 07. - Publication Year :
- 2010
-
Abstract
- The gene encoding the androgen receptor (AR) is associated with male pattern baldness (androgenetic alopecia - AGA). In case-control and family analyses, we mapped AR and the adjacent intergenic regions. We found evidence for association with two independent loci, one upstream and previously described and the other downstream and apparently novel. The haplotype comprising these SNPs was strongly associated with AGA (P = 3.75 × 10(-5)) in 1195 men. We also replicated association with a recently reported non-coding region on chromosome 20 and found that its association with AGA was less strong and independent of that of AR. Our results will help focus future efforts to further define AGA genetic risk.<br /> (© 2010 John Wiley & Sons A/S.)
- Subjects :
- Adolescent
Adult
Aged
Alopecia diagnosis
Chromosomes, Human, Pair 20 genetics
Epistasis, Genetic genetics
Gene Frequency genetics
Genes, X-Linked genetics
Genotype
Humans
Linkage Disequilibrium genetics
Male
Middle Aged
Xedar Receptor genetics
Young Adult
Alopecia genetics
Polymorphism, Single Nucleotide genetics
Receptors, Androgen genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0625
- Volume :
- 19
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Experimental dermatology
- Publication Type :
- Editorial & Opinion
- Accession number :
- 21073542
- Full Text :
- https://doi.org/10.1111/j.1600-0625.2010.01132.x