Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes.

Authors :: Pisani MJ
Weber DK
Heimann K
Collins JG
Keene FR
Source :: Metallomics : integrated biometal science [Metallomics] 2010 Jun; Vol. 2 (6), pp. 393-6. Date of Electronic Publication: 2010 Apr 23.
Publication Year :: 2010
Abstract: The lipophilic ligand-bridged dinuclear cation Rubb₁₆ is significantly cytotoxic and preferentially accumulates in the mitochondria of the L1210 murine leukemia cancer cell line.

Subjects :: Animals
Cell Line, Tumor
Leukemia L1210
Mice
Microscopy, Confocal
Mitochondria metabolism
Molecular Structure
Pyridines toxicity
Mitochondria drug effects
Organometallic Compounds chemistry
Organometallic Compounds toxicity
Pyridines chemistry
Ruthenium toxicity

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