O,O-dimethylthiophosphonosulfenyl bromide-silver triflate: a new powerful promoter system for the preactivation of thioglycosides.

Authors :: Peng P
Ye XS
Source :: Organic & biomolecular chemistry [Org Biomol Chem] 2011 Jan 21; Vol. 9 (2), pp. 616-22. Date of Electronic Publication: 2010 Nov 10.
Publication Year :: 2011
Abstract: O,O-Dimethylthiophosphonosulfenyl bromide (DMTPSB) in combination with silver triflate provides a powerful thiophilic promoter system. Both "armed" and "disarmed" thioglycoside glycosyl donors can be activated to form glycosidic linkages efficiently by the pre-activation protocol. The usefulness of this new promoter is illustrated by a successful iterative one-pot oligosaccharide assembly.

Subjects :: Glycosylation
Molecular Structure
Oligosaccharides chemistry
Bromides chemistry
Mesylates chemistry
Organothiophosphorus Compounds chemistry
Silver Compounds chemistry
Thioglycosides chemistry

Full Text Access

Tools