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Effects of percutaneous estradiol-oral progesterone versus oral conjugated equine estrogens-medroxyprogesterone acetate on breast cell proliferation and bcl-2 protein in healthy women.
- Source :
-
Fertility and sterility [Fertil Steril] 2011 Mar 01; Vol. 95 (3), pp. 1188-91. Date of Electronic Publication: 2010 Nov 10. - Publication Year :
- 2011
-
Abstract
- In a prospective, randomized clinical study 77 women were assigned randomly to receive sequential hormone therapy with either conventional oral conjugated equine estrogens (0.625 mg) with the addition on 14 of the 28 days of oral medroxyprogesterone acetate (5 mg) or natural E(2) gel (1.5 mg) with oral micronized P (200 mg) on 14 of the 28 days of each cycle. Because oral conjugated equine estrogens-medroxyprogesterone acetate induced a highly significant increase in breast cell proliferation in contrast to percutaneous E(2)-oral P with a difference between therapies approaching significance, the former therapy has a marked impact on the breast whereas natural percutaneous E(2)-oral micronized P has not.<br /> (Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Administration, Oral
Biopsy
Breast cytology
Breast metabolism
Breast Neoplasms epidemiology
Breast Neoplasms prevention & control
Cell Division drug effects
Contraceptive Agents, Female administration & dosage
Contraceptive Agents, Female adverse effects
Estrogen Replacement Therapy methods
Estrogens administration & dosage
Estrogens adverse effects
Estrogens, Conjugated (USP) administration & dosage
Female
Humans
Medroxyprogesterone Acetate administration & dosage
Prospective Studies
Risk Factors
Breast drug effects
Estrogen Replacement Therapy adverse effects
Estrogens, Conjugated (USP) adverse effects
Medroxyprogesterone Acetate adverse effects
Proto-Oncogene Proteins c-bcl-2 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 95
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 21067727
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2010.09.062