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EGFR mutation detection in NSCLC--assessment of diagnostic application and recommendations of the German Panel for Mutation Testing in NSCLC.
- Source :
-
Virchows Archiv : an international journal of pathology [Virchows Arch] 2011 Jan; Vol. 458 (1), pp. 95-8. Date of Electronic Publication: 2010 Nov 06. - Publication Year :
- 2011
-
Abstract
- EGFR mutation testing in non-small cell lung cancer (NSCLC) is a novel and important molecular pathological diagnostic assay that is predictive of response to anti-epidermal growth factor receptor (EGFR) therapy. A comprehensive compilation of a large number of EGFR mutation analyses of the German Panel for Mutation Analyses in NSCLC demonstrates (a) a higher than previously reported mutation frequency outside the conventionally tested exons 19 and 21 and (b) an overall superiority of sequencing based assays over mutation-specific PCR. The implications for future diagnostic EGFR mutation testing are discussed.
- Subjects :
- Exons genetics
Genetic Testing methods
Germany
Health Planning Guidelines
Humans
Single-Blind Method
Carcinoma, Non-Small-Cell Lung diagnosis
Carcinoma, Non-Small-Cell Lung genetics
Early Detection of Cancer methods
ErbB Receptors genetics
Lung Neoplasms diagnosis
Lung Neoplasms genetics
Mutation genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2307
- Volume :
- 458
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Virchows Archiv : an international journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 21057810
- Full Text :
- https://doi.org/10.1007/s00428-010-1000-y