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Differential itch- and pain-related behavioral responses and ยต-opoid modulation in mice.
- Source :
-
Acta dermato-venereologica [Acta Derm Venereol] 2010 Nov; Vol. 90 (6), pp. 575-81. - Publication Year :
- 2010
-
Abstract
- Intradermal microinjection of the pruritogen histamine, or the algogen capsaicin, in the mouse cheek differentially elicits mainly hindlimb scratching or ipsilateral forelimb wiping, respectively. We investigated the dose-dependency of these responses elicited by various pruritogens and algogens, and µ-opioid modulation. Histamine, 5-hydro-xytryptamine (5-HT) and agonists of protease-activated receptors PAR-2 and PAR-4, all elicited dose-related hindlimb scratching bouts with little forelimb wiping. In contrast, capsaicin, allyl isothiocyanate and bradykinin elicited dose-related forelimb wiping with little scratching. Morphine reduced capsaicin-evoked wiping but not pruritogen-evoked scratching. The µ-antagonist naltrexone decreased pruritogen-evoked scratching but not capsaicin-evoked wiping. A cowhage spicule inserted intradermal elicited equivalent scratching and wiping, while inactivated cowhage spicules loaded with histamine or capsaicin elicited significantly more scratching or wiping, respectively. The mouse cheek injection model appears to be a useful behavioral test that distinguishes between itch and pain.
- Subjects :
- Analgesics, Opioid pharmacology
Animals
Antigens, Plant administration & dosage
Capsaicin administration & dosage
Disease Models, Animal
Dose-Response Relationship, Drug
Histamine administration & dosage
Injections, Intradermal
Irritants administration & dosage
Male
Mice
Mice, Inbred ICR
Morphine pharmacology
Mucuna
Naltrexone pharmacology
Narcotic Antagonists pharmacology
Pain chemically induced
Pain prevention & control
Pain psychology
Pruritus chemically induced
Pruritus prevention & control
Pruritus psychology
Receptor, PAR-2 agonists
Receptor, PAR-2 metabolism
Receptors, Opioid, mu metabolism
Receptors, Thrombin agonists
Receptors, Thrombin metabolism
Time Factors
Behavior, Animal drug effects
Motor Activity drug effects
Pain metabolism
Pruritus metabolism
Receptors, Opioid, mu drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2057
- Volume :
- 90
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Acta dermato-venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 21057739
- Full Text :
- https://doi.org/10.2340/00015555-0962