Back to Search
Start Over
Hexaminolevulinate-mediated photodynamic purging of marrow grafts with murine breast carcinoma.
- Source :
-
Bone marrow transplantation [Bone Marrow Transplant] 2011 Aug; Vol. 46 (8), pp. 1118-27. Date of Electronic Publication: 2010 Nov 08. - Publication Year :
- 2011
-
Abstract
- Photodynamic therapy (PDT) with porphyrin precursors is an established therapy for certain tumors. This study aimed to explore the use of hexaminolevulinate (HAL), a porphyrin precursor, for photodynamic purging of BM grafts contaminated with cells of the 4T1 breast carcinoma cell line. The optimal PDT dose was not effective in eradicating 4T1 cells when the tumor cells were mixed with murine marrow cells in vitro. However, the number of pulmonary metastases was reduced, and the survival of experimental animals was prolonged substantially when they were subjected to TBI followed by transplantation of syngeneic BM containing metastasized 4T1 cells that had been treated ex vivo by HAL-PDT. Despite the failure of in vitro experiments, HAL-based photodynamic purging could be a useful modality for treating animals bearing an experimental breast carcinoma.
- Subjects :
- Aminolevulinic Acid pharmacokinetics
Aminolevulinic Acid pharmacology
Animals
Bone Marrow drug effects
Bone Marrow pathology
Cell Line, Tumor
Female
Hematopoietic Stem Cell Transplantation methods
Lung Neoplasms prevention & control
Lung Neoplasms secondary
Mice
Mice, Inbred BALB C
Photosensitizing Agents pharmacokinetics
Protoporphyrins pharmacokinetics
Protoporphyrins pharmacology
Tumor Cells, Cultured
Aminolevulinic Acid analogs & derivatives
Bone Marrow Purging methods
Mammary Neoplasms, Experimental drug therapy
Mammary Neoplasms, Experimental pathology
Photochemotherapy methods
Photosensitizing Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5365
- Volume :
- 46
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bone marrow transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 21057550
- Full Text :
- https://doi.org/10.1038/bmt.2010.277