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Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals.
- Source :
-
European journal of endocrinology [Eur J Endocrinol] 2011 Jan; Vol. 164 (1), pp. 75-82. Date of Electronic Publication: 2010 Nov 04. - Publication Year :
- 2011
-
Abstract
- Context: Vitamin D receptor (VDR) polymorphisms are associated with a variety of diseases, which may translate into an effect on mortality.<br />Objective: To investigate the associations between VDR gene variants and mortality among older people.<br />Design: The analyses were conducted in a population-based, prospective cohort of the Longitudinal Aging Study Amsterdam. Adequate DNA analysis was performed in 923 men and women (≥65 years). We aimed to assess the associations between mortality and the VDR polymorphism FokI, three haplotypes of the Cdx2 and GATA polymorphisms, and three haplotypes of the BsmI, ApaI, and TaqI polymorphisms.<br />Results: During the median follow-up of 10.7 years, 480 participants deceased (51%). Homozygosity for the Cdx2-GATA haplotype 1 allele was associated with a 30% higher mortality risk compared to the absence of alleles (hazard ratios (HR) 1.30, 95% confidence intervals (CI) 1.01-1.68). Adjustment for cardiovascular risk factors and 25-hydroxyvitamin D levels did not affect this HR. The number of copies of the Cdx2-GATA haplotype 1 allele was associated, although not significantly, with an increased risk of osteoporotic fractures (0 copies=reference, HR, 95% CI: 1 copy 2.01, 0.99-4.07 and 2 copies 1.81, 0.87-4.18). After adjustment for osteoporotic fractures, homozygosity for the Cdx2-GATA haplotype 1 allele was no longer associated with higher mortality risk (HR 1.08, 95% CI 0.83-1.41).<br />Conclusions: The Cdx2-GATA haplotype 1 allele was related to increased mortality risk, which may be partly explained by osteoporotic fractures. As the biological mechanism is uncertain and this study size is limited, our results should be interpreted as hypothesis generating.
- Subjects :
- Aged
Aged, 80 and over
CDX2 Transcription Factor
Cardiovascular Diseases genetics
Cardiovascular Diseases mortality
Cohort Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Leucine genetics
Male
Middle Aged
Neoplasms genetics
Neoplasms mortality
Netherlands epidemiology
Odds Ratio
Risk Assessment
Risk Factors
Deoxyribonucleases, Type II Site-Specific genetics
Haplotypes
Homeodomain Proteins genetics
Leucine analogs & derivatives
Mortality trends
Polymorphism, Genetic
Receptors, Calcitriol genetics
White People genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1479-683X
- Volume :
- 164
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 21051524
- Full Text :
- https://doi.org/10.1530/EJE-10-0688