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Tandem facial amphiphiles for membrane protein stabilization.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2010 Dec 01; Vol. 132 (47), pp. 16750-2. Date of Electronic Publication: 2010 Nov 04. - Publication Year :
- 2010
-
Abstract
- We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.
- Subjects :
- Bacteriorhodopsins chemistry
Deoxycholic Acid chemical synthesis
Hydrophobic and Hydrophilic Interactions
Maltose chemistry
Micelles
Protein Stability drug effects
Rhodobacter capsulatus
Time Factors
Water chemistry
Deoxycholic Acid chemistry
Deoxycholic Acid pharmacology
Membrane Proteins chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5126
- Volume :
- 132
- Issue :
- 47
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 21049926
- Full Text :
- https://doi.org/10.1021/ja1072959