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Central nervous system effects of lactate infusion in primates.
- Source :
-
Biological psychiatry [Biol Psychiatry] 1990 Jan 15; Vol. 27 (2), pp. 193-204. - Publication Year :
- 1990
-
Abstract
- The concentration of total lactate in cisternal fluid increased threefold, from 12.3 +/- 2.1 to 37.6 +/- 8.9 mg/dl, during a 20-min intravenous infusion of 1 M racemic sodium lactate (10 mEq/kg) in 3 anesthetized, mechanically ventilated baboons. Rises in cisternal lactate lagged behind arterial lactate increases, but occurred during the time interval in which susceptible humans typically panic in response to lactate infusion. Subsequent to cisternal lactate increases, cisternal pH and HCO3- concentration progressively increased during a 105-min interval following lactate infusion. No consistent changes in cisternal pCO2 occurred during or subsequent to lactate infusion. These preliminary findings fail to support the hypothesis that lactate-induced panic is mediated by increasing central nervous system pCO2. Instead, these data demonstrate that lactate can rapidly increase in the central nervous system during lactate infusion, suggesting new lines of investigation for studying the mechanisms responsible for lactate-induced panic.
- Subjects :
- Animals
Anxiety Disorders chemically induced
Blood Gas Analysis
Carbon Dioxide cerebrospinal fluid
Drug Administration Schedule
Female
Humans
Hydrogen-Ion Concentration
Infusions, Intravenous
Lactates administration & dosage
Lactates blood
Lactic Acid
Panic
Papio blood
Lactates cerebrospinal fluid
Lactates pharmacology
Papio cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3223
- Volume :
- 27
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 2104759
- Full Text :
- https://doi.org/10.1016/0006-3223(90)90649-m