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Genetic diversity of human zoonotic leishmaniasis in Iberian Peninsula.
- Source :
-
Zoonoses and public health [Zoonoses Public Health] 2011 Jun; Vol. 58 (4), pp. 234-7. Date of Electronic Publication: 2010 Oct 12. - Publication Year :
- 2011
-
Abstract
- Leishmaniasis caused by Leishmania (Leishmania) infantum is a zoonotic disease endemic in South Europe, from Portugal to the Middle East. The aim of the present study was to investigate the genetic diversity of L. infantum parasites in Iberian Peninsula. Twenty-four L. infantum strains isolated from immunocompetent patients with leishmaniasis from several localities of Portugal and Spain were studied. The use of kinetoplast DNA-PCR-restriction fragment length polymorphism as a molecular marker revealed intra-specific variation. No association was found between genotype and clinical form of the disease or patients age group. Two main clusters were identified with this marker: (i) zymodeme MON-1 strains and (ii) non-MON-1 strains. However, no association was found between strains variability and geographical distribution suggesting that parasite populations of different regions in the Iberian Peninsula are homogenous.<br /> (© 2010 Blackwell Verlag GmbH.)
- Subjects :
- Adolescent
Adult
Animals
DNA, Kinetoplast chemistry
Genotype
Humans
Leishmania infantum isolation & purification
Leishmaniasis, Cutaneous parasitology
Polymerase Chain Reaction
Portugal
Spain
Young Adult
Leishmania infantum genetics
Leishmaniasis, Visceral parasitology
Polymorphism, Genetic
Zoonoses parasitology
Subjects
Details
- Language :
- English
- ISSN :
- 1863-2378
- Volume :
- 58
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zoonoses and public health
- Publication Type :
- Academic Journal
- Accession number :
- 21040506
- Full Text :
- https://doi.org/10.1111/j.1863-2378.2010.01374.x