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Infinite mixture-of-experts model for sparse survival regression with application to breast cancer.
- Source :
-
BMC bioinformatics [BMC Bioinformatics] 2010 Oct 26; Vol. 11 Suppl 8, pp. S8. Date of Electronic Publication: 2010 Oct 26. - Publication Year :
- 2010
-
Abstract
- Background: We present an infinite mixture-of-experts model to find an unknown number of sub-groups within a given patient cohort based on survival analysis. The effect of patient features on survival is modeled using the Cox's proportionality hazards model which yields a non-standard regression component. The model is able to find key explanatory factors (chosen from main effects and higher-order interactions) for each sub-group by enforcing sparsity on the regression coefficients via the Bayesian Group-Lasso.<br />Results: Simulated examples justify the need of such an elaborate framework for identifying sub-groups along with their key characteristics versus other simpler models. When applied to a breast-cancer dataset consisting of survival times and protein expression levels of patients, it results in identifying two distinct sub-groups with different survival patterns (low-risk and high-risk) along with the respective sets of compound markers.<br />Conclusions: The unified framework presented here, combining elements of cluster and feature detection for survival analysis, is clearly a powerful tool for analyzing survival patterns within a patient group. The model also demonstrates the feasibility of analyzing complex interactions which can contribute to definition of novel prognostic compound markers.
- Subjects :
- Bayes Theorem
Breast Neoplasms diagnosis
Cluster Analysis
Cohort Studies
Computer Simulation
Databases, Factual
Female
Humans
Kaplan-Meier Estimate
Markov Chains
Monte Carlo Method
Prognosis
Proportional Hazards Models
Reproducibility of Results
Breast Neoplasms mortality
Models, Statistical
Regression Analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2105
- Volume :
- 11 Suppl 8
- Database :
- MEDLINE
- Journal :
- BMC bioinformatics
- Publication Type :
- Academic Journal
- Accession number :
- 21034433
- Full Text :
- https://doi.org/10.1186/1471-2105-11-S8-S8