Back to Search
Start Over
Study of specific immune response to unadsorbed concentrated tetanus vaccine administered by intradermal route to non-immunized persons in the last ten years.
- Source :
-
Archives roumaines de pathologie experimentales et de microbiologie [Arch Roum Pathol Exp Microbiol] 1990 Jan-Mar; Vol. 49 (1), pp. 51-62. - Publication Year :
- 1990
-
Abstract
- Investigations of anti-tetanus response, in 404 subjects, most of them aged 60, being non-immunized for at least 10 years, stressed out the fact that 28.7% were not protected and 6.18% presented a protecting titer of 0.01 IU/ml, evaluated by "in vivo" protection test in mice. Some subjects were immunized with unadsorbed Tetanus vaccine (10 Lf/0.1 ml/dose) by i.d. route, using Jet-injector, and the others with adsorbed Tetanus vaccine (0.5 ml/dose), by i.m. route, using the needle and syringe. The vaccines were well tolerated and adverse reactions were not recorded. After 30 days, a single vaccine dose produced a protecting effect in 97.45% of non-protected subjects, belonging to i.d. immunized group, and also in 93.33% belonging to i.m. immunized group. 30 days after the administration of a second dose, protection set up in all subjects, no matter of vaccine type and administration route used. For a continuous reduction of tetanus morbidity, the authors suggest a specific periodical immunization of non-protected persons, selected by serological screening, using unadsorbed Tetanus vaccine, administered by i.d. route by means of the Jet-injector.
- Subjects :
- Adsorption
Adult
Aged
Antibodies, Bacterial blood
Clostridium tetani immunology
Dose-Response Relationship, Immunologic
Female
Humans
Immunization
Injections, Intradermal
Injections, Intramuscular
Male
Middle Aged
Tetanus Toxoid administration & dosage
Tetanus Toxoid adverse effects
Time Factors
Antibody Specificity immunology
Tetanus Toxoid immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0004-0037
- Volume :
- 49
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Archives roumaines de pathologie experimentales et de microbiologie
- Publication Type :
- Academic Journal
- Accession number :
- 2101203