Back to Search
Start Over
The reduced extracellular calcium requirement for proliferation by neoplastic hepatocytes.
- Source :
-
In vitro [In Vitro] 1978 Jun; Vol. 14 (6), pp. 527-35. - Publication Year :
- 1978
-
Abstract
- Cells from neonatal rat livers were unable to maintain DNA-synthetic activity in calcium-deficient medium, but neoplastic hepatocytes from Morris hepatomas 5123 tc and 7795 synthesized DNA and proliferated indefinitely in this calcium-deficient medium. The calcium content of fresh hepatoma tissue from which these cultures were derived was as much as 10 times greater than that of normal liver; but this difference could not account for the insensitivity of neoplastic cells to extracellular calcium because it disappeared during subsequent cultivation in vitro.
Details
- Language :
- English
- ISSN :
- 0073-5655
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- In vitro
- Publication Type :
- Academic Journal
- Accession number :
- 210108
- Full Text :
- https://doi.org/10.1007/BF02616095