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Outcomes of hospitalized patients with bacteraemic and non-bacteraemic community-acquired pneumonia caused by Streptococcus pneumoniae.
- Source :
-
Epidemiology and infection [Epidemiol Infect] 2011 Sep; Vol. 139 (9), pp. 1307-16. Date of Electronic Publication: 2010 Oct 26. - Publication Year :
- 2011
-
Abstract
- In contrast to bacteraemic pneumococcal community-acquired pneumonia (CAP), there is a paucity of data on the clinical characteristics and outcomes of non-bacteraemic pneumococcal CAP. This retrospective study compared the outcome of hospitalized patients with bacteraemic and non-bacteraemic pneumococcal CAP treated at a medical centre from 2004 to 2008. Data on clinical outcomes including all-cause mortality, length of hospital stay, need for intensive-care unit admission and extrapulmonary involvement were analysed. In all, 221 patients with pneumococcal pneumonia (87 bacteraemic, 134 non-bacteraemic) were included. Patients with bacteraemic pneumococcal pneumonia (BPP) were older than those with non-BPP (46·2 ± 30·7 years vs. 21·7 ± 30·8 years, P<0·001) and were more likely to have underlying medical diseases (66·7% vs. 33·6%, P<0·001). The overall mortality rates at 7, 14, and 30 days were significantly higher in BPP than non-BPP patients (12·6% vs. 2·2%, 14·9% vs. 3·7%, 19·5% vs. 5·1%, all P<0·01). Multivariate logistic regression analysis showed that pneumococcal bacteraemia was correlated with extrapulmonary involvement (odds ratio 5·46, 95% confidence interval 1·97-15·16, P=0·001). In conclusion, S. pneumoniae bacteraemia increased the risk of mortality and extrapulmonary involvement in patients with pneumococcal CAP.
- Subjects :
- Adolescent
Adult
Aged
Child
Child, Preschool
Community-Acquired Infections diagnosis
Community-Acquired Infections therapy
Female
Hospital Mortality
Hospitalization
Humans
Male
Middle Aged
Pneumonia, Pneumococcal diagnosis
Pneumonia, Pneumococcal therapy
Retrospective Studies
Risk Factors
Severity of Illness Index
Streptococcus pneumoniae isolation & purification
Taiwan epidemiology
Treatment Outcome
Bacteremia mortality
Community-Acquired Infections mortality
Length of Stay
Pneumonia, Pneumococcal mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1469-4409
- Volume :
- 139
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Epidemiology and infection
- Publication Type :
- Academic Journal
- Accession number :
- 20974020
- Full Text :
- https://doi.org/10.1017/S0950268810002402