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Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.
- Source :
-
Science (New York, N.Y.) [Science] 2010 Nov 12; Vol. 330 (6006), pp. 980-2. Date of Electronic Publication: 2010 Oct 21. - Publication Year :
- 2010
-
Abstract
- The intracerebral injection of β-amyloid-containing brain extracts can induce cerebral β-amyloidosis and associated pathologies in susceptible hosts. We found that intraperitoneal inoculation with β-amyloid-rich extracts induced β-amyloidosis in the brains of β-amyloid precursor protein transgenic mice after prolonged incubation times.
- Subjects :
- Alzheimer Disease metabolism
Alzheimer Disease pathology
Amyloid beta-Peptides administration & dosage
Amyloid beta-Peptides metabolism
Animals
Brain blood supply
Brain Chemistry
Cerebral Amyloid Angiopathy metabolism
Cerebral Amyloid Angiopathy pathology
Female
Injections, Intraperitoneal
Mice
Mice, Transgenic
Plaque, Amyloid pathology
Prions chemistry
Prions metabolism
Protein Folding
Time Factors
Amyloid beta-Peptides chemistry
Brain pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 330
- Issue :
- 6006
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 20966215
- Full Text :
- https://doi.org/10.1126/science.1194516