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Skeletal manifestations of systemic autoimmune diseases.
- Source :
-
Current opinion in endocrinology, diabetes, and obesity [Curr Opin Endocrinol Diabetes Obes] 2010 Dec; Vol. 17 (6), pp. 540-5. - Publication Year :
- 2010
-
Abstract
- Purpose of Review: There is an increased risk of osteoporotic fractures and osteonecrosis often at a young age among patients with certain systemic autoimmune diseases. The loss of bone mineral density and bone integrity seen with these diseases often cannot be explained by traditional risk factors alone. In this review, we focus on rheumatoid arthritis and systemic lupus erythematosus, two systemic autoimmune diseases in which skeletal manifestations have been well described.<br />Recent Findings: There is recent evidence that autoimmunity and its associated inflammation and vitamin D deficiency play key roles in the pathogenesis of adverse skeletal effects.<br />Summary: Understanding these processes carries implications for the prevention and treatment of osteoporosis and osteonecrosis among patients with autoimmune diseases.
- Subjects :
- Autoimmune Diseases therapy
Bone Diseases prevention & control
Bone Diseases therapy
Bone and Bones immunology
Humans
Inflammation physiopathology
Osteonecrosis epidemiology
Osteonecrosis immunology
Osteonecrosis prevention & control
Osteonecrosis therapy
Osteoporotic Fractures epidemiology
Osteoporotic Fractures immunology
Osteoporotic Fractures prevention & control
Osteoporotic Fractures therapy
Vitamin D physiology
Vitamin D Deficiency physiopathology
Vitamin D Deficiency prevention & control
Autoimmune Diseases physiopathology
Bone Diseases epidemiology
Bone Diseases immunology
Bone and Bones physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1752-2978
- Volume :
- 17
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Current opinion in endocrinology, diabetes, and obesity
- Publication Type :
- Academic Journal
- Accession number :
- 20962632
- Full Text :
- https://doi.org/10.1097/MED.0b013e328340533d