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Transcutaneous port for continuous duodenal levodopa/carbidopa administration in Parkinson's disease.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2011 Feb 01; Vol. 26 (2), pp. 331-4. Date of Electronic Publication: 2010 Oct 19. - Publication Year :
- 2011
-
Abstract
- Motor fluctuations in Parkinson's disease (PD) can be reduced by intraduodenal infusion of levodopa-carbidopa (Duodopa®) via percutaneous endoscopic gastrojejunostomy (PEG). We applied the transcutaneous soft-tissue anchored titanium port (T-port) in 15 PD patients with motor fluctuations; 7 Duodopa-naive (non-PEG), and 8 previously receiving Duodopa (former-PEG). Motor scores (UPDRS-III) and quality of life (QOL, PDQ-8) were assessed at baseline and 6 month follow-up. Six patients had local irritation shortly after implantation, persisting in one patient at 6 month follow-up, which led to explantation. After having finished the protocol, four T-ports were explanted in total. UPDRS-III and PDQ-8 scores improved moderately in the non-PEG patients, but remained similar in the former-PEG users. Two former-PEG users developed polyneuropathy. No obstructions, retractions, or leakages occurred. Technical and hygienic properties of the T-port were preferred by most patients. The T-port seems to be suitable for most PD patients qualifying for Duodopa therapy, although local infection may lead to explantation during longer-term follow-up.<br /> (Copyright © 2010 Movement Disorder Society.)
- Subjects :
- Administration, Cutaneous
Adult
Aged
Antiparkinson Agents therapeutic use
Carbidopa therapeutic use
Drug Combinations
Female
Humans
Levodopa therapeutic use
Male
Middle Aged
Patient Satisfaction
Quality of Life
Severity of Illness Index
Treatment Outcome
Antiparkinson Agents administration & dosage
Carbidopa administration & dosage
Duodenum
Levodopa administration & dosage
Parkinson Disease drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1531-8257
- Volume :
- 26
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 20960486
- Full Text :
- https://doi.org/10.1002/mds.23408