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Catalytic asymmetric formal [4 + 1] annulation leading to optically active cis-isoxazoline N-oxides.
- Source :
-
Organic letters [Org Lett] 2010 Dec 03; Vol. 12 (23), pp. 5402-5. Date of Electronic Publication: 2010 Oct 19. - Publication Year :
- 2010
-
Abstract
- The catalytic asymmetric synthesis of densely functionalized cis-isoxazoline N-oxides was realized with novel use of an organocatalyst, (S)-2-(azidodiphenylmethyl)pyrrolidine (4e) (Tan, B.; Zhu, D.; Zhang, L.; Chua, P. J.; Zeng, X.; Zhong, G. Chem.-Eur. J. 2010, 16, 3842; Olivares-Romero, J. L.; Juaristi, E. Tetrahedron 2008, 64, 9992), via an elegant formal [4 + 1] annulation strategy using readily available 2-nitroacrylates and α-iodoaldehydes.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 12
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 20958089
- Full Text :
- https://doi.org/10.1021/ol102181r