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Transplanted mesenchymal stem cells can inhibit the three developmental stages of murine acute graft-versus-host disease.
- Source :
-
In vivo (Athens, Greece) [In Vivo] 2010 Sep-Oct; Vol. 24 (5), pp. 659-66. - Publication Year :
- 2010
-
Abstract
- Background: Recent data have demonstrated that mesenchymal stem cells (MSCs) have potent immune regulation capacity in vitro, enhancing their therapeutic appeal for their utilisation in the management of acute graft-versus-host disease (aGvHD). However, their immunoregulatory activity in vivo is largely unknown.<br />Materials and Methods: Using murine compact bone-derived MSCs in an aGvHD model, the phenotypic status of splenocytes of aGvHD and aGvHD+MSC groups of mice were examined by flow cytometry.<br />Results: MSC infusion decreased the expression of MHC-II and CD69 molecules on splenic CD11b+ cells of aGvHD mice, which resulted in decreased maturation of antigen-presenting cells. Moreover, the down-regulated ratio of CD3+CD69+ to CD3+ cells, leading to restrained early activation and effector T-cell formation, resulted in the enhancement of the absolute and relative number of splenic CD3+ cells by MSCs co-transfer.<br />Conclusion: This study demonstrated that MSCs can inhibit the three developmental stages of aGvHD.
- Subjects :
- Acute Disease
Animals
Antigens, CD metabolism
Antigens, Differentiation, T-Lymphocyte metabolism
CD11b Antigen metabolism
CD3 Complex metabolism
Cells, Cultured
Disease Models, Animal
Female
Flow Cytometry
Graft vs Host Disease immunology
Immunophenotyping
Lectins, C-Type metabolism
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Spleen cytology
Spleen immunology
T-Lymphocytes immunology
Graft vs Host Disease therapy
Mesenchymal Stem Cell Transplantation methods
Mesenchymal Stem Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7549
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- In vivo (Athens, Greece)
- Publication Type :
- Academic Journal
- Accession number :
- 20952730