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Thrombogenicity of sirolimus-eluting stents and bare metal stents: evaluation in the early phase after stent implantation.
- Source :
-
In vivo (Athens, Greece) [In Vivo] 2010 Sep-Oct; Vol. 24 (5), pp. 635-9. - Publication Year :
- 2010
-
Abstract
- Background: Thrombogenicitiy of drug-eluting stents is a matter of controversial debate. The aim of this study was to evaluate the thrombogenicity of sirolimus-eluting stents (SES) compared to bare metal stents (BMS) in a standardised in vitro model.<br />Materials and Methods: Nine SES and nine BMS were implanted in tubing loops and nine loops without stent served as controls. Initially and after 90 minutes of blood circulation in a modified chandler loop model, thrombin-antithrombin III complex (TAT), PMN-elastase, factor XIIa, SC5b-9, sP-selectin and platelet count were measured. Expression of CD62P, CD45/41 and PAC-1 on platelets were determined by flow cytometry.<br />Results: After 90 minutes, platelet count decreased significantly in the loops with BMS and SES (p<0.05). Levels of TAT, PMN-elastase and SC5b-9 were significantly elevated after 90 minutes in all loops (p<0.05). sP-selectin significantly increased in the loops with BMS and SES after 90 minutes. No significant changes occurred in any flow cytometric data. Platelet count, sP-selectin, TAT, PMN-elastase, SC5b-9, CD62P, CD41/CD45 and PAC-1 showed no significant difference between BMS and SES.<br />Conclusion: These data provide evidence that there is no difference in thrombogenicity of BMS and SES in the in vitro model.
- Subjects :
- Adult
Biomarkers
Blood Platelets metabolism
Cell Adhesion Molecules metabolism
Flow Cytometry
Humans
In Vitro Techniques
Male
Microscopy, Electron, Scanning
P-Selectin blood
Platelet Aggregation
Platelet Count
Young Adult
Drug-Eluting Stents adverse effects
Immunosuppressive Agents adverse effects
Metals adverse effects
Sirolimus adverse effects
Thrombosis chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7549
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- In vivo (Athens, Greece)
- Publication Type :
- Academic Journal
- Accession number :
- 20952726