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Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2010 Nov 15; Vol. 18 (22), pp. 8026-34. Date of Electronic Publication: 2010 Sep 16. - Publication Year :
- 2010
-
Abstract
- In this study, we investigated the effects of 24 chalcone derivatives from 2-naphthylacetophenone toward a lymphoblastic leukemia cell line (L1210). Three compounds, called R7, R13, and R15, presented concentration- and time-dependent cytotoxicity and induced cellular death by apoptosis via mitochondrial injury and oxidative stress. The effects of these compounds appear to occur through different mechanisms because R13 and R7 induced a greater disturbance of mitochondrial potential, and all compounds induced disturbances of cellular ATP content and increased caspase-3 activity before cellular death. These compounds also interfered with antioxidant enzymes activities and GSH content through different mechanisms.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents therapeutic use
Antineoplastic Agents toxicity
Cell Line, Tumor
Chalcone therapeutic use
Chalcone toxicity
Chalcones therapeutic use
Chalcones toxicity
Humans
Reactive Oxygen Species metabolism
Antineoplastic Agents chemistry
Apoptosis
Caspase 3 metabolism
Chalcone analogs & derivatives
Chalcones chemistry
Leukemia drug therapy
Mitochondria drug effects
Oxidative Stress
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 18
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20952199
- Full Text :
- https://doi.org/10.1016/j.bmc.2010.09.025