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Characterization of pathogen-specific expression of host immune response genes in Anaplasma and Mycobacterium species infected ruminants.
- Source :
-
Comparative immunology, microbiology and infectious diseases [Comp Immunol Microbiol Infect Dis] 2010 Dec; Vol. 33 (6), pp. e133-42. Date of Electronic Publication: 2010 Oct 16. - Publication Year :
- 2010
-
Abstract
- Anaplasma and Mycobacterium species are among the most prevalent bacterial pathogens in European red deer (Cervus elaphus) in south-central Spain and are known to modify gene expression in ruminants. In this study, we used microarray hybridization and real-time RT-PCR analyses to characterize global gene expression profiles in red deer in response to Anaplasma ovis and A. ovis/Mycobacterium bovis/Mycobacterium avium sub. paratuberculosis (MAP) infections, compare the expression of immune response genes between red deer infected with A. ovis, M. bovis and A. ovis/M. bovis/MAP, and characterize the differential expression of immune response genes identified in red deer in cattle infected with M. bovis and Anaplasma marginale. Global gene differential expression in A. ovis- and A. ovis/M. bovis/MAP-infected deer resulted in the modification of common and pathogen-specific cellular biological processes. The differential expression of host immune response genes showed pathogen and host-specific signatures and the effect of infection with multiple pathogens on deer immune response. These results suggested that intracellular bacteria from Anaplasma and Mycobacterium genera produce similar genes expression patterns in infected ruminants. However, pathogen and host-specific differences could contribute to disease diagnosis and treatment in ruminants.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Anaplasmosis genetics
Animals
Cattle
Cattle Diseases genetics
Gene Expression Profiling
Mycobacterium Infections genetics
Mycobacterium Infections immunology
Mycobacterium avium subsp. paratuberculosis immunology
Mycobacterium bovis immunology
Oligonucleotide Array Sequence Analysis
Polymerase Chain Reaction
Anaplasma ovis immunology
Anaplasmosis immunology
Cattle Diseases immunology
Deer genetics
Deer immunology
Deer microbiology
Gene Expression Regulation
Genes, MHC Class II
Mycobacterium immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1667
- Volume :
- 33
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Comparative immunology, microbiology and infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 20952064
- Full Text :
- https://doi.org/10.1016/j.cimid.2010.09.001