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Liposomes from soya phospholipids as percutaneous drug carriers. 1st communication: qualitative in vivo investigations with antibody-loaded liposomes.
- Source :
-
Arzneimittel-Forschung [Arzneimittelforschung] 1990 Dec; Vol. 40 (12), pp. 1363-5. - Publication Year :
- 1990
-
Abstract
- The penetration behaviour of liposome (prepared from NAT 106)-incorporated proteins was investigated in vivo by use of monoclonal antibodies (MOAB) as model substances on the skin of young pigs. Within 20 min of topical application, an even distribution of liposome-incorporated antibodies through all skin layers could be shown by means of an immunohistochemical stain.
- Subjects :
- Administration, Topical
Animals
Antibodies, Monoclonal pharmacokinetics
Female
Immunohistochemistry
Skin metabolism
Skin Absorption
Swine
Antibodies, Monoclonal administration & dosage
Drug Carriers chemistry
Liposomes chemistry
Phospholipids chemistry
Skin anatomy & histology
Glycine max analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0004-4172
- Volume :
- 40
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Arzneimittel-Forschung
- Publication Type :
- Academic Journal
- Accession number :
- 2095134