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IL28B and the control of hepatitis C virus infection.
- Source :
-
Gastroenterology [Gastroenterology] 2010 Dec; Vol. 139 (6), pp. 1865-76. Date of Electronic Publication: 2010 Oct 13. - Publication Year :
- 2010
-
Abstract
- Treatment-induced control and spontaneous clearance of hepatitis C virus (HCV) infection are affected by various host factors. Polymorphisms in the region of the gene IL28B are associated with HCV clearance, implicating the gene product, interferon (IFN)-λ3, in the immune response to HCV. Although it is not clear how the IL28B haplotype affects HCV clearance, IFN-λ3 up-regulates interferon-stimulated genes, similar to IFN-α and IFN-β but via a different receptor. There is also evidence that IFN-λ3 affects the adaptive immune response. The IL28B genotype can be considered, along with other factors, in predicting patient responses to therapy with pegylated IFN-α and ribavirin. We review the genetic studies that uncovered the association between IL28B and HCV clearance, the biology of IFN-λ3, the clinical implications of the genetic association, and areas of future research.<br /> (Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1528-0012
- Volume :
- 139
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 20950615
- Full Text :
- https://doi.org/10.1053/j.gastro.2010.10.004