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Real-life dosage and clinical efficacy of biphasic insulin preparations in patients with type 2 diabetes.
- Source :
-
Advances in therapy [Adv Ther] 2010 Nov; Vol. 27 (11), pp. 859-69. Date of Electronic Publication: 2010 Oct 14. - Publication Year :
- 2010
-
Abstract
- Introduction: This retrospective study used data from a primary care database to compare two insulin products in routine clinical practice for the treatment of type 2 diabetes in the UK.<br />Patients and Methods: Records were analyzed for patients with type 2 diabetes who had been initiated on biphasic insulin aspart 30 (BIAsp30) (n=632) or biphasic isophane human insulin 30 (BHI30) (n=762) and who had a glycated hemoglobin (HbA₁(c)) measurement at baseline (up to 6 months before the index date) and end of study (6-12 months after index date). Regression analyses were used to test for a statistically significant interaction between reduction in HbA₁(c) from baseline to end of study and the log-transformed average daily dose (logADD) of insulin.<br />Results: With BIAsp30 a significantly lower dose of insulin (47.74 insulin units [IU]/day vs. 66.63 IU/day, P<0.0001) was required to obtain a similar HbA₁(c) reduction (1.71%-point vs. 1.55%-point, P=0.24). To achieve an additional reduction of 0.1 percentage points in HbA₁(c) (eg, reduction from 9% to 7.9% HbA₁(c) instead of from 9% to 8%), the dose of BIAsp30 would need to be increased by a factor of 1.15. For BHI30, a greater increase in dose would be needed to achieve the same additional HbA₁(c) reduction (dose increase by a factor of 1.74).<br />Conclusion: Clinically meaningful reductions in HbA₁(c) can be achieved at lower insulin doses with BIAsp30 treatment than with BHI30. Lower insulin doses may have important implications for medication costs.
- Subjects :
- Biphasic Insulins
Dose-Response Relationship, Drug
Female
Glycated Hemoglobin drug effects
Humans
Hypoglycemic Agents administration & dosage
Insulin administration & dosage
Insulin pharmacology
Insulin Aspart
Insulin, Isophane administration & dosage
Linear Models
Male
Middle Aged
Multivariate Analysis
Retrospective Studies
United Kingdom
Diabetes Mellitus, Type 2 drug therapy
Hypoglycemic Agents pharmacology
Insulin analogs & derivatives
Insulin, Isophane pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1865-8652
- Volume :
- 27
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Advances in therapy
- Publication Type :
- Academic Journal
- Accession number :
- 20949340
- Full Text :
- https://doi.org/10.1007/s12325-010-0079-5