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CCL2 and CCR2 variants are associated with skeletal muscle strength and change in strength with resistance training.

Authors :
Harmon BT
Orkunoglu-Suer EF
Adham K
Larkin JS
Gordish-Dressman H
Clarkson PM
Thompson PD
Angelopoulos TJ
Gordon PM
Moyna NM
Pescatello LS
Visich PS
Zoeller RF
Hubal MJ
Tosi LL
Hoffman EP
Devaney JM
Source :
Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2010 Dec; Vol. 109 (6), pp. 1779-85. Date of Electronic Publication: 2010 Oct 14.
Publication Year :
2010

Abstract

Baseline muscle size and muscle adaptation to exercise are traits with high variability across individuals. Recent research has implicated several chemokines and their receptors in the pathogenesis of many conditions that are influenced by inflammatory processes, including muscle damage and repair. One specific chemokine, chemokine (C-C motif) ligand 2 (CCL2), is expressed by macrophages and muscle satellite cells, increases expression dramatically following muscle damage, and increases expression further with repeated bouts of exercise, suggesting that CCL2 plays a key role in muscle adaptation. The present study hypothesizes that genetic variations in CCL2 and its receptor (CCR2) may help explain muscle trait variability. College-aged subjects [n = 874, Functional Single-Nucleotide Polymorphisms Associated With Muscle Size and Strength (FAMUSS) cohort] underwent a 12-wk supervised strength-training program for the upper arm muscles. Muscle size (via MR imaging) and elbow flexion strength (1 repetition maximum and isometric) measurements were taken before and after training. The study participants were then genotyped for 11 genetic variants in CCL2 and five variants in CCR2. Variants in the CCL2 and CCR2 genes show strong associations with several pretraining muscle strength traits, indicating that inflammatory genes in skeletal muscle contribute to the polygenic system that determines muscle phenotypes. These associations extend across both sexes, and several of these genetic variants have been shown to influence gene regulation.

Details

Language :
English
ISSN :
1522-1601
Volume :
109
Issue :
6
Database :
MEDLINE
Journal :
Journal of applied physiology (Bethesda, Md. : 1985)
Publication Type :
Academic Journal
Accession number :
20947712
Full Text :
https://doi.org/10.1152/japplphysiol.00633.2010