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CCL2 and CCR2 variants are associated with skeletal muscle strength and change in strength with resistance training.
- Source :
-
Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2010 Dec; Vol. 109 (6), pp. 1779-85. Date of Electronic Publication: 2010 Oct 14. - Publication Year :
- 2010
-
Abstract
- Baseline muscle size and muscle adaptation to exercise are traits with high variability across individuals. Recent research has implicated several chemokines and their receptors in the pathogenesis of many conditions that are influenced by inflammatory processes, including muscle damage and repair. One specific chemokine, chemokine (C-C motif) ligand 2 (CCL2), is expressed by macrophages and muscle satellite cells, increases expression dramatically following muscle damage, and increases expression further with repeated bouts of exercise, suggesting that CCL2 plays a key role in muscle adaptation. The present study hypothesizes that genetic variations in CCL2 and its receptor (CCR2) may help explain muscle trait variability. College-aged subjects [n = 874, Functional Single-Nucleotide Polymorphisms Associated With Muscle Size and Strength (FAMUSS) cohort] underwent a 12-wk supervised strength-training program for the upper arm muscles. Muscle size (via MR imaging) and elbow flexion strength (1 repetition maximum and isometric) measurements were taken before and after training. The study participants were then genotyped for 11 genetic variants in CCL2 and five variants in CCR2. Variants in the CCL2 and CCR2 genes show strong associations with several pretraining muscle strength traits, indicating that inflammatory genes in skeletal muscle contribute to the polygenic system that determines muscle phenotypes. These associations extend across both sexes, and several of these genetic variants have been shown to influence gene regulation.
- Subjects :
- Adaptation, Physiological
Adolescent
Adult
Biomechanical Phenomena
Chemokine CCL2 metabolism
Chi-Square Distribution
Female
Gene Frequency
Genotype
Humans
Linkage Disequilibrium
Magnetic Resonance Imaging
Male
Muscle, Skeletal anatomy & histology
Phenotype
Receptors, CCR2 metabolism
Time Factors
Torque
United States
Upper Extremity
Young Adult
Chemokine CCL2 genetics
Isometric Contraction genetics
Muscle Strength genetics
Muscle, Skeletal metabolism
Polymorphism, Single Nucleotide
Receptors, CCR2 genetics
Resistance Training
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1601
- Volume :
- 109
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of applied physiology (Bethesda, Md. : 1985)
- Publication Type :
- Academic Journal
- Accession number :
- 20947712
- Full Text :
- https://doi.org/10.1152/japplphysiol.00633.2010