Mitochondrial diseases and the role of the yeast models.

Authors :: Rinaldi T
Dallabona C
Ferrero I
Frontali L
Bolotin-Fukuhara M
Source :: FEMS yeast research [FEMS Yeast Res] 2010 Dec; Vol. 10 (8), pp. 1006-22. Date of Electronic Publication: 2010 Oct 14.
Publication Year :: 2010
Abstract: Nowadays, mitochondrial diseases are recognized and studied with much attention and they cannot be considered anymore as 'rare diseases'. Yeast has been an instrumental organism to understand the genetic and molecular aspects of the many roles of mitochondria within the cells. Thanks to the general conservation of mitochondrial genes and pathways between human and yeast, it can also be used to model some diseases. In this review, we focus on the most recent topics, exemplifying those for which yeast models have been especially valuable.<br /> (© 2010 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.)