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Immunoscintigraphy with 131I or 111In labelled OC 125 F(ab')2 fragments in patients with ovarian carcinoma.
- Source :
-
The International journal of biological markers [Int J Biol Markers] 1990 Oct-Dec; Vol. 5 (4), pp. 159-65. - Publication Year :
- 1990
-
Abstract
- To evaluate the clinical usefulness of immunoscintigraphy with OC 125 in ovarian carcinoma, we studied 25 patients suspected of having ovarian carcinoma or in follow-up after surgery. Fourteen patients were studied with 131I-OC 125 F(ab')2 and 11 with 111In-OC 125 F(ab')2. No differences were observed with the use of either radionuclide. Global diagnostic indexes obtained were S = 100%, Sp = 44,5% and A = 81%. The low specificity obtained was remarkable: 5 false positive results in two uterine myomas, one abscess, one follicular cyst and one granulation tissue scar. On the other hand, all lesions of ovarian carcinoma were detected. Analysis of the evolution of tumor/background (T/B) uptake ratios from the first to the second day of exploration revealed a tendency for the ratio to diminish significantly (greater than 15%) in false positive cases with the exception of the abscess while this did not happen in true positive cases, with the exception of a regional recurrence. Analysis of T/B ratio variations could contribute towards elevating the test's specificity.
- Subjects :
- Antigens, Tumor-Associated, Carbohydrate blood
Evaluation Studies as Topic
Female
Humans
Immunoglobulin Fab Fragments
Indium Radioisotopes
Iodine Radioisotopes
Ovarian Neoplasms diagnostic imaging
Ovarian Neoplasms immunology
Radionuclide Imaging
Antibodies, Monoclonal
Biomarkers, Tumor immunology
Ovarian Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0393-6155
- Volume :
- 5
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The International journal of biological markers
- Publication Type :
- Academic Journal
- Accession number :
- 2093731
- Full Text :
- https://doi.org/10.1177/172460089000500401