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Tissue-specific differences in mitochondrial activity and biogenesis.
- Source :
-
Mitochondrion [Mitochondrion] 2011 Jan; Vol. 11 (1), pp. 207-13. Date of Electronic Publication: 2010 Oct 07. - Publication Year :
- 2011
-
Abstract
- Each cell type develops and maintains a specific oxidative phosphorylation (OXPHOS) capacity to satisfy its metabolic and energetic demands. This implies that there are differences between tissues in mitochondrial number, function, protein composition and morphology. The OXPHOS system biogenesis requires the coordinated expression of both mitochondrial and nuclear genomes. Mitochondrial DNA (mtDNA) expression can be regulated at different levels (replication, transcription, translation and post-translational levels) to contribute to the final observed OXPHOS activities. By analyzing five mammalian tissues, we evaluated the differences in the cellular amount of mtDNA and its correlation with the final observed mitochondrial activity.<br /> (Copyright © 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.)
- Subjects :
- Animals
Cell Nucleus genetics
Cell Nucleus metabolism
Citrate (si)-Synthase
DNA, Mitochondrial genetics
DNA, Mitochondrial metabolism
Electron Transport Complex IV
Female
Male
Mitochondria genetics
Muscle, Skeletal metabolism
Oxidative Phosphorylation
Rats
Rats, Wistar
Transcription, Genetic
DNA, Mitochondrial analysis
Gene Dosage
Gene Expression Regulation
Mitochondria metabolism
Organ Specificity
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8278
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Mitochondrion
- Publication Type :
- Academic Journal
- Accession number :
- 20933104
- Full Text :
- https://doi.org/10.1016/j.mito.2010.09.011