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[Sonographic ovarian vascularization and volume in women with polycystic ovary syndrome treated with clomiphene citrate and metformin].
- Source :
-
Ginecologia y obstetricia de Mexico [Ginecol Obstet Mex] 2010 Jan; Vol. 78 (1), pp. 58-64. - Publication Year :
- 2010
-
Abstract
- Objective: To measure the vascularization and ovarian volume with three-dimensional sonography in patients diagnosed of polycystic ovary syndrome with stimulated ovulation treatment, and to analyse the differences between the patients treated with clomiphen citrate versus clomiphen citrate and metformin.<br />Material and Method: Therty patients were studied. Twenty ovulation cycles were obtained with clomiphen citrate and 17 with clomiphen citrate plus merformin (added in case of obesity or hyperglucemy/hyperinsulinemia). Ovarian volumes and vascular indexes were studied with 3D-sonography and results were analysed by treatment.<br />Results: There were no statistical differences of ovarian volume by treatment along the cycles, although bigger volume were found in ovulatory cycles compared to non-ovulatory ones (20,36 versus 13,89 ml, p = 0,026). No statistical differences were also found concerning vascular indexes, neither by treatment nor by the obtention of ovulation in the cycle.<br />Conclusions: Ovarian volume and vascular indexes measured with three-dimensional sonography in patients diagnosed of polycystic ovary syndrome do not show differents values in patients treated with clomiphen citrate alone versus clomiphen citrate plus metformin.
- Subjects :
- Adult
Clomiphene administration & dosage
Clomiphene adverse effects
Clomiphene pharmacology
Drug Therapy, Combination
Female
Fertility Agents, Female adverse effects
Fertility Agents, Female pharmacology
Humans
Hyperglycemia diagnostic imaging
Hyperglycemia drug therapy
Hyperglycemia etiology
Hyperglycemia pathology
Hyperinsulinism diagnostic imaging
Hyperinsulinism drug therapy
Hyperinsulinism etiology
Hyperinsulinism pathology
Metformin administration & dosage
Metformin adverse effects
Metformin pharmacology
Neovascularization, Physiologic drug effects
Obesity diagnostic imaging
Obesity drug therapy
Obesity etiology
Obesity pathology
Organ Size drug effects
Ovary blood supply
Ovary diagnostic imaging
Polycystic Ovary Syndrome complications
Polycystic Ovary Syndrome diagnostic imaging
Polycystic Ovary Syndrome pathology
Prospective Studies
Treatment Outcome
Ultrasonography, Doppler
Young Adult
Clomiphene therapeutic use
Fertility Agents, Female therapeutic use
Metformin therapeutic use
Ovary drug effects
Ovulation Induction
Polycystic Ovary Syndrome drug therapy
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0300-9041
- Volume :
- 78
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Ginecologia y obstetricia de Mexico
- Publication Type :
- Academic Journal
- Accession number :
- 20931804