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[Protective effect of hydroxysafflor yellow A against acute lung injury induced by oleic acid and lipopolysaccharide in rats].
- Source :
-
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2010 Jul; Vol. 45 (7), pp. 940-4. - Publication Year :
- 2010
-
Abstract
- This study is to investigate the pharmacological effect and mechanism of action of hydroxysafflor yellow A (HSYA) on acute lung injury (ALI). The rat ALI was induced by oleic acid and lipopolysaccharide (LPS) injection. The incidence of acidosis, PaO2 (arterial blood oxygen pressure), W/D (wet weight/dry weight) and lung index (LI) were measured. Electron microscope and optical microscope were applied to observe lung morphological changes in rat. RT-PCR was used to determine TNF-alpha and ICAM-1 mRNA level. Inhibition effect of HSYA on plasma inflammatory cytokine expression was measured by ELISA. HSYA could alleviate pulmonary edema, reduce acidosis, keep PaO2 from descending, inhibit inflammatory cell infiltration, inhibit rat lung TNF-alpha and ICAM-1 mRNA expression and plasma IL-6 and IL-1beta level elevation. HSYA is an effective ingredient to remit ALI induced by oleic acid and LPS in rat.
- Subjects :
- Acute Lung Injury chemically induced
Acute Lung Injury metabolism
Animals
Chalcone isolation & purification
Chalcone pharmacology
Flowers chemistry
Intercellular Adhesion Molecule-1 genetics
Intercellular Adhesion Molecule-1 metabolism
Interleukin-1beta blood
Interleukin-6 blood
Lipopolysaccharides
Lung metabolism
Lung ultrastructure
Male
Oleic Acid
Plants, Medicinal chemistry
Quinones isolation & purification
RNA, Messenger metabolism
Rats
Rats, Wistar
Tumor Necrosis Factor-alpha genetics
Tumor Necrosis Factor-alpha metabolism
Acute Lung Injury pathology
Carthamus tinctorius chemistry
Chalcone analogs & derivatives
Lung pathology
Quinones pharmacology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0513-4870
- Volume :
- 45
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Yao xue xue bao = Acta pharmaceutica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 20931796