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The microstructural integrity of the corpus callosum and associated impulsivity in alcohol dependence: a tractography-based segmentation study using diffusion spectrum imaging.
- Source :
-
Psychiatry research [Psychiatry Res] 2010 Nov 30; Vol. 184 (2), pp. 128-34. - Publication Year :
- 2010
-
Abstract
- Previous post-mortem and structural magnetic resonance imaging (MRI) studies in patients with alcohol dependence have demonstrated abnormalities of brain white matter. The present study investigated the microstructural integrity in the corpus callosum and the associations of this integrity with neurobehavioral assessments. Twenty-five male cases fulfilling the DSM-IV diagnosis of alcohol dependence and 15 male control subjects were scanned using a 3T MRI system. Callosal fiber tracts were reconstructed by diffusion spectrum imaging tractography and were subdivided into seven functionally distinct segments. The microstructural integrity was quantified in terms of generalized fractional anisotropy (GFA). Compared with normal subjects, men with alcohol dependence showed lower GFA values on all segments of the corpus callosum. The segment interconnecting the bilateral orbitofrontal cortices was the most affected. The score on the Barratt Impulsivity Scale showed an inverse relationship with GFA on the callosal fiber tracts connecting the bilateral orbitofrontal cortices. Furthermore, the duration of regular use was negatively associated with GFA on the callosal fiber tracts connecting the bilateral temporal and parietal cortices. Our findings suggest that a high self-rated impulsivity level was associated with low anisotropy in white matter of corpus callosum sectors extending to the orbitofrontal cortex.<br /> (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Alcoholism physiopathology
Anisotropy
Brain Mapping methods
Corpus Callosum physiopathology
Humans
Image Processing, Computer-Assisted
Impulsive Behavior physiopathology
Male
Middle Aged
Surveys and Questionnaires
Alcoholism pathology
Corpus Callosum pathology
Diffusion Tensor Imaging
Impulsive Behavior pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-1781
- Volume :
- 184
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 20926265
- Full Text :
- https://doi.org/10.1016/j.pscychresns.2010.07.002