6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty.

Subjects

Subjects :

Alkylating Agents pharmacology
Analgesia
Binding, Competitive
Morphine antagonists & inhibitors
Naltrexone chemical synthesis
Naltrexone pharmacology
Nitrogen Mustard Compounds chemical synthesis
Nitrogen Mustard Compounds pharmacology
Alkylating Agents chemical synthesis
Naloxone analogs & derivatives
Naltrexone analogs & derivatives
Narcotic Antagonists chemical synthesis
Receptors, Opioid drug effects

Details

Language :

English

ISSN :

0022-2623

Volume :

21

Issue :

7

Database :

MEDLINE

Journal :

Journal of medicinal chemistry

Publication Type :

Academic Journal

Accession number :

209185

Full Text :

https://doi.org/10.1021/jm00205a002