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6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 1978 Jul; Vol. 21 (7), pp. 598-9. - Publication Year :
- 1978
- Subjects :
- Alkylating Agents pharmacology
Analgesia
Binding, Competitive
Morphine antagonists & inhibitors
Naltrexone chemical synthesis
Naltrexone pharmacology
Nitrogen Mustard Compounds chemical synthesis
Nitrogen Mustard Compounds pharmacology
Alkylating Agents chemical synthesis
Naloxone analogs & derivatives
Naltrexone analogs & derivatives
Narcotic Antagonists chemical synthesis
Receptors, Opioid drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2623
- Volume :
- 21
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 209185
- Full Text :
- https://doi.org/10.1021/jm00205a002