High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man.

Authors :: Vree TB
Beneken Kolmer EW
Hekster YA
Source :: Pharmaceutisch weekblad. Scientific edition [Pharm Weekbl Sci] 1990 Dec 14; Vol. 12 (6), pp. 243-6.
Publication Year :: 1990
Abstract: A direct high pressure liquid chromatographic analysis of sulfaphenazole-N2-glucuronide in urine is described. After an oral dose of 439 mg of sulfaphenazole, 0% is excreted unchanged in the urine, less than 1% is excreted as N4-acetylsulfaphenazole. As N2-glucuronide 49.4% is excreted in one slow acetylator and 84.8% in one fast acetylator.

Subjects :: Acetylation
Chromatography, High Pressure Liquid
Glucuronates metabolism
Glucuronidase
Half-Life
Humans
Male
Phenotype
Protein Binding
Sulfaphenazole blood
Sulfaphenazole urine
Sulfaphenazole analogs & derivatives
Sulfaphenazole pharmacokinetics

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