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Carbazoles and coumarins from Clausena harmandiana stimulate glucose uptake in L6 myotubes.
- Source :
-
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2010 Dec; Vol. 90 (3), pp. e67-71. - Publication Year :
- 2010
-
Abstract
- Two carbazoles (compounds 1 and 2) and one coumarin (compound 8) from Clausena harmandiana exhibited significant glucose uptake activity in L6 myotubes in a time and dose dependent manner. In addition, compounds 2 and 8 were inhibited by p38 mitogen-activated protein kinases and phosphatidylinositol 3-kinases, respectively.<br /> (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Cell Survival drug effects
Cells, Cultured
Clausena chemistry
Cycloheximide pharmacology
Cytochalasin B pharmacology
Deoxyglucose metabolism
Humans
Imidazoles pharmacology
Muscle Fibers, Skeletal drug effects
Plant Extracts pharmacology
Plant Roots chemistry
Pyridines pharmacology
p38 Mitogen-Activated Protein Kinases antagonists & inhibitors
Carbazoles pharmacology
Coumarins pharmacology
Muscle Fibers, Skeletal metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8227
- Volume :
- 90
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Diabetes research and clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 20888659
- Full Text :
- https://doi.org/10.1016/j.diabres.2010.09.005