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Design and validation of a highly discriminatory 10-locus Y-chromosome STR multiplex system.
- Source :
-
Forensic science international. Genetics [Forensic Sci Int Genet] 2011 Mar; Vol. 5 (2), pp. 122-5. Date of Electronic Publication: 2010 Sep 29. - Publication Year :
- 2011
-
Abstract
- The Y-chromosome STRs (short tandem repeat) markers are routinely utilized in the resolution of forensic casework related to sexual assault. For this, the forensic community has adopted a set of eleven (core) Y-STR that is incorporated in all commercial diagnostic systems. Our previous studies of Y-STR polymorphisms in the South African population identified low levels of diversity and discrimination capacity for many commercial marker sets, determining a limited applicability of these systems to the local population groups. To overcome this shortcoming, we designed a Y-STR 10-plex system that shows higher discriminatory capacity (DC) than available commercial systems. The markers were selected from a population group of 283 individuals with African, European and Asian ancestry genotyped at 45 Y-STRs, applying an optimization based selection procedure to achieve the highest possible DC with the minimal number of markers. The 10-plex was satisfactorily subjected to developmental validation tests following the SWGDAM guidelines and shows potential for its application to genealogical and evolutionary studies.<br /> (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-0326
- Volume :
- 5
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Forensic science international. Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 20884311
- Full Text :
- https://doi.org/10.1016/j.fsigen.2010.08.015