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Molecular mechanisms underlying the control of antigenic variation in African trypanosomes.
- Source :
-
Current opinion in microbiology [Curr Opin Microbiol] 2010 Dec; Vol. 13 (6), pp. 700-5. Date of Electronic Publication: 2010 Sep 29. - Publication Year :
- 2010
-
Abstract
- African trypanosomes escape the host adaptive immune response by switching their dense protective coat of Variant Surface Glycoprotein (VSG). Each cell expresses only one VSG gene at a time from a telomeric expression site (ES). The 'pre-genomic' era saw the identification of the range of pathways involving VSG recombination in the context of mono-telomeric VSG transcription. A prominent feature of the early post-genomic era is the description of the molecular machineries involved in these processes. We describe the factors and sequences recently linked to mutually exclusive transcription and VSG recombination, and how these act in the control of the key virulence mechanism of antigenic variation.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- DNA, Protozoan genetics
Gene Expression Regulation
Immune Evasion
Recombination, Genetic
Telomere
Transcription, Genetic
Trypanosoma brucei gambiense genetics
Trypanosoma brucei gambiense immunology
Trypanosomiasis, African parasitology
Variant Surface Glycoproteins, Trypanosoma genetics
Antigenic Variation
Trypanosoma brucei gambiense physiology
Variant Surface Glycoproteins, Trypanosoma immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0364
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Current opinion in microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 20884281
- Full Text :
- https://doi.org/10.1016/j.mib.2010.08.009