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[Effect of buprenorphine on external pancreatic secretion in rats].

Authors :
Nagain C
Chariot J
Roze C
Vaille C
Source :
Annales pharmaceutiques francaises [Ann Pharm Fr] 1990; Vol. 48 (5), pp. 248-54.
Publication Year :
1990

Abstract

2-deoxyglucose stimulates pancreatic secretion through a mainly vagal neural pathway. Buprenorphine antagonized this stimulation in a dose-related fashion between 0.017 and 0.45 mg/kg. i.v. The effect of buprenorphine was suppressed by naloxone, but not by alpha and beta-adrenoceptor blocking agents. The effect of methadone was similar, at doses about ten times larger.

Subjects

Subjects :
Animals
Buprenorphine antagonists & inhibitors
Deoxyglucose antagonists & inhibitors
Dose-Response Relationship, Drug
Male
Methadone pharmacology
Naloxone pharmacology
Pancreas drug effects
Rats
Rats, Inbred Strains
Buprenorphine pharmacology
Pancreas metabolism

Details

Language :
French
ISSN :
0003-4509
Volume :
48
Issue :
5
Database :
MEDLINE
Journal :
Annales pharmaceutiques francaises
Publication Type :
Academic Journal
Accession number :
2088160

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Authors Abstract Subjects Details