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Late relapse in patients with diffuse large B-cell lymphoma.
- Source :
-
British journal of haematology [Br J Haematol] 2010 Nov; Vol. 151 (4), pp. 354-8. Date of Electronic Publication: 2010 Sep 29. - Publication Year :
- 2010
-
Abstract
- The outcomes for 162 patients with diffuse large B-cell lymphoma treated with a CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone)-like regimen who obtained a complete remission and who subsequently relapsed after ≥5 years of remission (late relapse, N=30), or <5 years of remission (early relapse, N=132), were compared. The late relapsing patients had better prognostic characteristics at diagnosis, such as stage I/II disease (73% vs. 49%, P=0·04), a normal lactic dehydrogenase (77% vs. 48%, P=0·01), and a Karnofsky performance score of ≥80 (100% vs. 86%, P=0·01). The 3-year survival after relapse was better in late relapsing patients (48% vs. 25%, P=0·03), but the survival at 5 years (32% vs. 20%) and 10 years (13% vs. 14%) after relapse was not different. A multivariate analysis of factors predicting survival after relapse found age (P<0·0001) and presence of B-symptoms (P=0·03) to predict survival, but not early versus late relapse. A small percentage of the late relapsing patients can have a prolonged second remission. However, the overall survival from the time of relapse was not different between early and late relapsing patients with most succumbing to lymphoma.<br /> (© 2010 Blackwell Publishing Ltd.)
- Subjects :
- Adult
Age Factors
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Biomarkers, Tumor blood
Cyclophosphamide therapeutic use
Doxorubicin therapeutic use
Epidemiologic Methods
Female
Humans
L-Lactate Dehydrogenase blood
Lymphoma, Large B-Cell, Diffuse diagnosis
Lymphoma, Large B-Cell, Diffuse pathology
Male
Middle Aged
Neoplasm Staging
Prednisolone therapeutic use
Prognosis
Recurrence
Remission Induction
Time Factors
Vincristine therapeutic use
Young Adult
Lymphoma, Large B-Cell, Diffuse drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 151
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 20880118
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2010.08330.x