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Protective effects of indomethacin and cyclophosphamide but not of infliximab on liver metabolic changes caused by adjuvant-induced arthritis.
- Source :
-
Inflammation [Inflammation] 2011 Dec; Vol. 34 (6), pp. 519-30. - Publication Year :
- 2011
-
Abstract
- In the study, indomethacin, cyclophosphamide, and infliximab were administered to adjuvant-induced arthritic rats to determine if they were able to prevent the abnormalities caused by arthritis on hepatic metabolism. The drugs were administered to arthritic rats, and at the clinical onset of arthritis (day 14 after adjuvant injection), the livers were perfused to evaluate gluconeogenesis, ureagenesis, oxygen uptake, L: -lactate, pyruvate, and ammonia release from L: -alanine. The effects of the drugs on body weight gain and the signs of arthritis (paw edema, appearance of secondary lesions, and weights of lymphoid tissues) were also evaluated. Cyclophosphamide could completely prevent liver metabolic changes and the inflammatory response. Indomethacin restored ureagenesis, minimized the decrease in gluconeogenesis, and exerted a partially beneficial effect on inflammatory reactions. Infliximab did not improve arthritis-induced liver metabolic alterations or inflammatory responses. These results suggest the participation of prostaglandins, but not TNF-α, on arthritis-induced liver metabolic alterations.
- Subjects :
- Animals
Antibodies, Monoclonal therapeutic use
Arthritis, Experimental metabolism
Cyclophosphamide therapeutic use
Indomethacin therapeutic use
Inflammation
Infliximab
Liver metabolism
Prostaglandins
Protective Agents
Rats
Treatment Outcome
Tumor Necrosis Factor-alpha
Antibodies, Monoclonal pharmacology
Arthritis, Experimental drug therapy
Cyclophosphamide pharmacology
Indomethacin pharmacology
Liver drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2576
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 20878352
- Full Text :
- https://doi.org/10.1007/s10753-010-9259-3