Stringent programming of DNA methylation in humans.

Authors :: Aung HT
Harrison DK
Findlay I
Mattick JS
Martin NG
Carroll BJ
Source :: Twin research and human genetics : the official journal of the International Society for Twin Studies [Twin Res Hum Genet] 2010 Oct; Vol. 13 (5), pp. 405-11.
Publication Year :: 2010
Abstract: We describe a PCR-based method called Amplified Methylation Polymorphism (AMP) for scanning genomes for DNA methylation changes. AMP detects tissue-specific DNA methylation signatures often representing junctions between methylated and unmethylated DNA close to intronexon junctions and/or associated with CpG islands. Identical AMP profiles are detected for healthy, young, monozygotic twins.

Subjects :: Adolescent
Animals
Base Sequence
CpG Islands
DNA Primers genetics
Exons
Genetic Markers
Humans
Introns
Mice
Nucleic Acid Amplification Techniques methods
Polymerase Chain Reaction methods
Polymorphism, Genetic
DNA Methylation genetics
Twins, Monozygotic genetics

Language :: English
ISSN :: 1832-4274
Volume :: 13
Issue :: 5
Database :: MEDLINE
Journal :: Twin research and human genetics : the official journal of the International Society for Twin Studies
Publication Type :: Academic Journal
Accession number :: 20874461
Full Text :: https://doi.org/10.1375/twin.13.5.405