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Do anticholinergics affect reaction time? A possible impact on the course of rehabilitation.
- Source :
-
NeuroRehabilitation [NeuroRehabilitation] 2010; Vol. 27 (2), pp. 141-5. - Publication Year :
- 2010
-
Abstract
- Objective: To assess if oxybutynin and tolterodine have an effect on simple reaction time in healthy volunteers.<br />Methods: Simple reaction time was evaluated before and 90 minutes after the oral administration of oxybutynin and tolterodine in a cross-over design. Twenty seven healthy volunteers, aged 26 to 48 years, were included in the study. The electromyographic activity of the flexor digitorum superficialis muscle that was used for the response was recorded, and premotor time was measured.<br />Results: The mean age of the study group was 33.1 ± 7.4 years. Mean premotor times before oxybutynin and before tolterodine administration were statistically non-significant. Mean premotor times after the administration of oxybutynin and tolterodine were significantly longer than the initial premotor times (p = 0.003).<br />Conclusions: The results of the study showed that oxybutynin and tolterodine prolonged the simple reaction time. The prolonged simple reaction time may suggest a perceptive impairment. The potential for perceptive impairment as a side effect of oxybutynin and tolterodine might suggest a negative impact on the rehabilitation interventions and the activities of daily living because of central nervous system effects.
- Subjects :
- Administration, Oral
Adult
Benzhydryl Compounds administration & dosage
Cholinergic Antagonists administration & dosage
Cresols administration & dosage
Cross-Over Studies
Electric Stimulation
Female
Hand physiology
Humans
Male
Mandelic Acids administration & dosage
Middle Aged
Muscle, Skeletal physiology
Neuropsychological Tests
Phenylpropanolamine administration & dosage
Reaction Time physiology
Reference Values
Tolterodine Tartrate
Benzhydryl Compounds pharmacology
Cholinergic Antagonists pharmacology
Cresols pharmacology
Electromyography
Mandelic Acids pharmacology
Muscle, Skeletal drug effects
Phenylpropanolamine pharmacology
Reaction Time drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1878-6448
- Volume :
- 27
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- NeuroRehabilitation
- Publication Type :
- Academic Journal
- Accession number :
- 20871143
- Full Text :
- https://doi.org/10.3233/NRE-2010-0590