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Humoral immunity of dTap-IPV vaccine (REPEVAX®) administered one month after dT-IPV vaccine (REVAXIS®) in adults with unknown vaccination history.
- Source :
-
Human vaccines [Hum Vaccin] 2010 Oct; Vol. 6 (10), pp. 829-34. Date of Electronic Publication: 2010 Oct 01. - Publication Year :
- 2010
-
Abstract
- This study was to assess the humoral immune response induced by a vaccination schedule routinely used in France in 18-50 year old adults with unknown vaccination history. In this monocentric, prospective study, subjects received one dose of REVAXIS® (dT-IPV, diphtheria, tetanus and poliomyelitis (inactivated) vaccine (adsorbed, reduced antigen(s) content)) (Visit 1) followed by one dose of REPEVAX® (dTap-IPV, diphtheria, tetanus, pertussis (acellular, component) and poliomyelitis (inactivated) vaccine (adsorbed, reduced antigen(s) content)) one month later (Visit 2). Antibodies against diphtheria, tetanus, poliomyelitis types 1, 2 and 3, and pertussis toxin (PT) were measured one month after the administration of REPEVAX® (Visit 3). A total of 136 subjects were included in the study, but blood samples were available for only 73 subjects. Their mean age at inclusion was 33.2 ± 7.3 years. 49.3% of the 73 subjects originated from the WHO African Region, 6.8% from the WHO Western Pacific Region and 5.5% from the WHO European Region. One month after REPEVAX® administration, all subjects had seroprotective antibody titers against diphtheria and tetanus (≥0.1 IU/mL), poliomyelitis types 2 and 3 (≥ 8 1/dil); one subject (1.4%) did not have antibodies against poliomyelitis type 1. The rate of anti-PT seropositivity (≥8 EU/mL) was 94.4%. One dose of REPEVAX® administered one month after a dose of REVAXIS® in subjects with unknown vaccination history induced a high humoral response. These results validate a vaccination schedule routinely used for years that rapidly elicits effective immunization against diphtheria, tetanus, poliomyelitis and pertussis.
- Subjects :
- Adolescent
Adult
Female
France
Humans
Immunization Schedule
Male
Middle Aged
Prospective Studies
Vaccines, Combined immunology
Young Adult
Antibodies, Bacterial blood
Antibodies, Viral blood
Diphtheria Toxoid administration & dosage
Diphtheria Toxoid immunology
Diphtheria-Tetanus-Pertussis Vaccine administration & dosage
Diphtheria-Tetanus-Pertussis Vaccine immunology
Immunization, Secondary methods
Pertussis Vaccine administration & dosage
Pertussis Vaccine immunology
Poliovirus Vaccine, Inactivated administration & dosage
Poliovirus Vaccine, Inactivated immunology
Poliovirus Vaccines immunology
Tetanus Toxoid administration & dosage
Tetanus Toxoid immunology
Vaccination methods
Subjects
Details
- Language :
- English
- ISSN :
- 1554-8619
- Volume :
- 6
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Human vaccines
- Publication Type :
- Academic Journal
- Accession number :
- 20864810
- Full Text :
- https://doi.org/10.4161/hv.6.10.12582