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Inhibitors of membrane transmethylation reactions prevent the lymphocyte chemokinetic response.
- Source :
-
Immunology letters [Immunol Lett] 1990 Dec; Vol. 26 (3), pp. 211-5. - Publication Year :
- 1990
-
Abstract
- The methylation of membrane phospholipids has been shown to occur following receptor-mediated activation of leukocytes. The present studies show that the human lymphocyte response to two positive chemokinetic signals (bradykinin and lymphocyte chemoattractant factor) can be interrupted by inhibitors of S-adenosyl-L-methionine-mediated transmethylation reactions. The chemokinetic response to the nonphysiologic stimulant colchicine is not affected. We speculate that phospholipid methylation accompanies receptor-mediated lymphocyte migration, and may facilitate activation of second messenger systems.
- Subjects :
- Adenine pharmacology
Adenosine Deaminase Inhibitors
Animals
Bradykinin pharmacology
Colchicine pharmacology
Homocysteine analogs & derivatives
Homocysteine pharmacology
Humans
Interleukin-16
Leukocytes, Mononuclear drug effects
Lymphocytes drug effects
Lymphokines pharmacology
Male
Methylation drug effects
Rats
Rats, Inbred Strains
S-Adenosylmethionine metabolism
Second Messenger Systems
Adenine analogs & derivatives
Chemotaxis, Leukocyte drug effects
Membrane Lipids metabolism
Phospholipids metabolism
S-Adenosylmethionine antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0165-2478
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Immunology letters
- Publication Type :
- Academic Journal
- Accession number :
- 2086448
- Full Text :
- https://doi.org/10.1016/0165-2478(90)90148-j