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The relationship between pKa and skin irritation for a series of basic penetrants in man.
- Source :
-
Fundamental and applied toxicology : official journal of the Society of Toxicology [Fundam Appl Toxicol] 1990 Nov; Vol. 15 (4), pp. 760-6. - Publication Year :
- 1990
-
Abstract
- For a series of bases, which penetrate through human skin in vitro at similar rates (0.056-0.49 microM/cm2/hr), penetrant pKa is shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and redness measurements are highly linearly correlated. For the selected series, irritation becomes significant for bases with a pKa greater than 8. The irritation potential of acids with pKa less than or equal to 4 has been previously reported; pKa appears highly predictive of acute skin irritation for acids and bases in man.
- Subjects :
- Adult
Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid
Edema chemically induced
Edema pathology
Erythema chemically induced
Erythema pathology
Female
Humans
In Vitro Techniques
Irritants chemistry
Male
Middle Aged
Skin pathology
Skin Absorption
Skin Diseases pathology
Irritants toxicity
Skin Diseases chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0272-0590
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Fundamental and applied toxicology : official journal of the Society of Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 2086317
- Full Text :
- https://doi.org/10.1016/0272-0590(90)90192-m