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The relationship between pKa and skin irritation for a series of basic penetrants in man.

Authors :
Berner B
Wilson DR
Steffens RJ
Mazzenga GC
Hinz R
Guy RH
Maibach HI
Source :
Fundamental and applied toxicology : official journal of the Society of Toxicology [Fundam Appl Toxicol] 1990 Nov; Vol. 15 (4), pp. 760-6.
Publication Year :
1990

Abstract

For a series of bases, which penetrate through human skin in vitro at similar rates (0.056-0.49 microM/cm2/hr), penetrant pKa is shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and redness measurements are highly linearly correlated. For the selected series, irritation becomes significant for bases with a pKa greater than 8. The irritation potential of acids with pKa less than or equal to 4 has been previously reported; pKa appears highly predictive of acute skin irritation for acids and bases in man.

Details

Language :
English
ISSN :
0272-0590
Volume :
15
Issue :
4
Database :
MEDLINE
Journal :
Fundamental and applied toxicology : official journal of the Society of Toxicology
Publication Type :
Academic Journal
Accession number :
2086317
Full Text :
https://doi.org/10.1016/0272-0590(90)90192-m