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Steric and charge factors in the resistance of uridylyl(3' - 5')N6-(N-threonylcarbonyl)adenosine to venom phosphodiesterase hydrolysis.

Authors :
Boryski J
Golankiewicz B
Source :
Biochimica et biophysica acta [Biochim Biophys Acta] 1978 Jun 09; Vol. 524 (2), pp. 491-6.
Publication Year :
1978

Abstract

The contribution of steric and negative charge factors to the resistance of uridylyl(3' - 5')N6-(N-threonylcarbonyl)adenosine to venom phosphodiesterase was investigated. The hydrolysis rates of uridylyl(3'-5')N6-(N-threonylcarbonyl)-adenosine, its model derivatives, methyl ester and O-benzyl ester, together with unmodified uridyly (3'-5')adenosine, were studied. It was found that the contribution of both factors is of the same order. The steric inhibition of digestion is distinctly higher than that confirmed by N6-(delta2-isopentenyl)adenosine [1], which is ascribed to the rigid conformation of the threonylcarbonyladenosine side chain.

Details

Language :
English
ISSN :
0006-3002
Volume :
524
Issue :
2
Database :
MEDLINE
Journal :
Biochimica et biophysica acta
Publication Type :
Academic Journal
Accession number :
208627
Full Text :
https://doi.org/10.1016/0005-2744(78)90188-2